Reciprocally, endothelial cells maintain CSC stem-like characteristics and enhance CSC-driven tumor growth by releasing soluble factors, including bFGF, and activating specific intracellular pathways, such as the Hedgehog pathway in glioma cancer cells and the NANOGP8 pathway in colorectal cancer cells, in different cancer types [86]. The gene discussed is FGF2; the disease is neoplasm.