Preclinical studies have demonstrated the efficacy of STAT3 pathway inhibitors, such as Stattic [257], C188-9 [258], OPB-31121 [259], OPB-51602 [260], AZD9150 [261], and STAT3 decoy oligonucleotide [262], as well as drugs targeting IL6/IL6R, including Siltuximab [263], Tocilizumab [264], and Olamkicept [265], across various tumor models. This evidence concerns the gene STAT3 and neoplasm.