For instance, Type I collagen, the most abundant collagen protein, enhances stemness-related characteristics in cancer cells, upregulates stemness-related markers like CD133 and Bmi1 in human colorectal cancers through α2β1 integrin, and provides support for the niche required for CD133+ glioblastoma stem cells (GSCs) maintenance and growth [91]. This evidence concerns the gene PROM1 and colorectal cancer.