Over recent decades, the exploration of cancer immunology has identified a spectrum of inhibitory immunoreceptors, including but not limited to programmed cell death protein 1 (PD-1), cytotoxic T lymphocyte-associated protein 4 (CTLA-4), lymphocyte-activation gene 3 (LAG3), T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), and B and T lymphocyte attenuator (BTLA) [121]. The gene discussed is CTLA4; the disease is cancer.