A quantitative analysis showed that the inflammatory infiltration area increased significantly in the livers of 4.5-month-old TNF-Tg mice compared to that in WT mice (Fig. 1B), and the area of liver fibrosis was significantly increased in 4.5- and 5.5-month-old TNF-Tg mice (Fig. 1C). This evidence concerns the gene TNF and Hepatic fibrosis.