These findings revealed the capability of the targeted NPs to induce higher cell death rates in CRC CEA-expressing MSI and MSS cells within 24 h, in contrast with free 5-FU, which takes 72 h to impact cancer cell in the same way (IC50 = 75 μM) (Fig. 6B) [50–52]. The gene discussed is CEACAM5; the disease is colorectal carcinoma.