Notably, LCN2 was also shown to be upregulated in ductular reactive cells during CCl4-induced liver fibrosis model and in the NASH model induced by Choline-Deficient L-Amino Acid-Defined High-Fat Diet (CDAHFD) [36, 37] (Fig. 4a). This evidence concerns the gene LCN2 and metabolic dysfunction-associated steatohepatitis.