SPP1 and neoplasm: CAFs produce angiogenesis regulators, such as VEGFA, PDGFC, FGF2, CXCL12, osteopontin, and CSF3 to promote the growth of tumor-associated blood vessels by recruiting myeloid cells and accelerate tumor angiogenesis by attracting vascular endothelial cells and recruiting monocytes [5, 49, 113].