It is important to note that CAF.ERα( +) (estrogen receptor alpha) can impede the metastasis and invasion of prostate cancer by inhibiting macrophage infiltration and modulating the expression of thrombospondin 2 (Thbs2) and MMPs [205, 206], which emphasizes the need for caution in targeting CAF. The gene discussed is ESR1; the disease is Familial prostate cancer.