Further analysis showed that ovarian cancer patients with high level of CITED2, LYVE1, OGN, RAP1A, and TBC1D22A had a poor prognosis that that with level of CITED2, LYVE1, OGN, RAP1A, and TBC1D22A (Supplementary Fig. 5B, all p < 0.05). This evidence concerns the gene RAP1A and ovarian cancer.