In 159 patients with esophageal cancer who received 5-FU- and cisplatin-based preoperative chemotherapy, high expression of PINK1 was correlated with poor response to neoadjuvant chemotherapy, thus suggesting that PINK1-mediated mitophagy contributes to resistance to 5-FU-based neoadjuvant therapy [17]. Here, PINK1 is linked to esophageal cancer.