The silencing of the BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 (BNIP3) in CRC and the high expression of PTEN-induced putative kinase 1 (PINK1) in esophageal cancer are associated with resistance to 5-FU-based chemotherapy [17, 18]. The gene discussed is BNIP3; the disease is colorectal carcinoma.