This is further supported by ERα slowing down RV remodeling among female rats with pulmonary hypertension [7], as well as by Cheng et al., who induced RV hypertrophy, via pulmonary artery banding (PAB), among male rats, as well as both wild-type (WT) and ERα loss-of-function mutant females [18]. This evidence concerns the gene ESR1 and pulmonary hypertension.