On the other hand, this cohort included elderly patients with pathological history such as chronic respiratory, cardiovascular and renal disease and oncological pathologies, all of which seem to induce muscle atrophy through a common pathway that is the activation of the renin angiotensin aldosterone system (RAS), An active RAS with elevated angiotensin II levels is harmful, producing: insulin resistance, muscle atrophy and fibrosis. This evidence concerns the gene AGT and kidney disorder.