We and others have previously shown that group 3 MBs have an aberrantly high expression of class I histone deacetylase 2 (HDAC2) [6, 7] and that MYC-amplified group 3 MB cells are highly sensitive to class I HDAC inhibition in vitro and in vivo [6, 8]. The gene discussed is MYC; the disease is Mobius syndrome.