On the other hand, contrary to the former findings, osteonecrosis zones could only seldom be observed, whereas the experimental model in mice reported frequent osteonecrosis detected following either the experimental induction of periodontitis [32] or tooth extraction with or without peri-apical pathologies under the administration of either Zo or RANKL inhibitors [33, 34]. The gene discussed is TNFSF11; the disease is periodontitis.