One fascinating gene with reduced expression levels in Stat4ΔLysMLdlr−/−, compared with Stat4fl/flLdlr−/− mice, when challenged with the HFD-C diet, was amyloid beta precursor protein (APP), supporting our as yet untested hypothesis that Stat4 plays a role, through neuroinflammation, in the progression of AD. This evidence concerns the gene APP and Alzheimer disease.