IGFBP2 and cancer: Illumina high-throughput sequencing revealed significant differences at the transcriptomic level between the high-fat diet group and the normal diet group, with high-fat diet upregulating genes including ITGA4, FSCN1, TWIST1 and IGFBP2 that play cancer promoting roles in various aspects of cancer cell growth, motile migration, invasion, metastatic recurrence as well as predicting prognosis.