IGFBP2 and neoplasm: Among the more significantly upregulated genes in the high-fat group were the ITGA4 gene, which plays a role in cell motility and migration34,35, the FSCN1 gene, which plays a role in metastasis of a variety of cancers36–38, the TWIST1 gene, which promotes tumor cell invasion and metastatic recurrence39–41, and the IGFBP2 gene, which promotes the growth of several tumors and predicts prognosis42–44, among others.