Aberrant activation of cGAS-STING signaling has been shown to be closely associated with autoimmune and inflammatory diseases such as rheumatoid arthritis (RA)55, Aicardi Goutières syndrome (AGS)27,28, systemic lupus erythematosus (SLE)30,31 and COVID-1956. Here, CGAS is linked to Aicardi-Goutieres syndrome.