In consistent with the in vitro results, intravenous administration of XQ2B (10 mg/kg) significantly impaired the production of IFN-β and CXCL10 upon HSV-1 infection in mice (Fig. 6b, c), and thus promoted virus infection in the brain tissues of mice (Fig. 6d, e). This evidence concerns the gene CXCL10 and viral infectious disease.