GSEA was performed on the cluster of cancer epithelial cell, we found that CHRGs enriched cells were mainly enriched in annotated pathways of P450-related drug metabolism and silenced tumor microenvironment, as well as the functions of cellular transition metal ions homeostasis, intracellular lipid transport and xenobiotic metabolic process (Fig. 9E, F). The gene discussed is CYP2B6; the disease is neoplasm.