Previously, preconditioning CSps with pericardial fluid obtained from myocardial infarction was prepared by our colleagues Zhang et al., and the paracrine function and survival rate of the pericardial fluid-pretreated CSps dramatically increased, exhibiting significant improvement of MI cardiac function, and the DiR-labeled CSps showed cTnT-positive in the infarcted area, indicating the direct differentiation of CSps into cardiomyocytes32. The gene discussed is TNNT2; the disease is myocardial infarction.