Erythema was characterized by a bolstered signature of immediate early genes (NR4A1, FOSL1, FOSB, ATF3, NR4A2) and immune system (CD163, C1QB, C1QC, THY1, MS4A7) that are inferentially expressed mainly in keratinocytes and myeloid cells, respectively, in skin tissue, along with Treg specific genes (CCR4, CNTNAP1, DUSP4, LMNA, PI16) in PBMC. This evidence concerns the gene PI16 and Erythema.