IL17A and systemic lupus erythematosus: Studies examining the role of IL-17 in lupus erythematosus, to investigate the efficacy of anti-IL-17 immunobiological medications, reported an increase in IL-17 expression in SAL and DLE lesions and in unaffected skin of SLE + patients, compared to healthy controls.8, 13 In our sample, IL-17 expression was significantly higher in CLE/SLE- patients, suggesting that anti-IL-17 drugs could be effective for CLE lesions.