Previous studies have shown a predominance of CD8+ cells in the lesions of patients with DLE, while in other skin subtypes more frequently associated with systemic disease, such as SAL, there is a predominance of CD4+ cells.17, 18 Other studies emphasized only the role of Granzyme B in CLE lesions, without considering the possible association with systemic disease.14, 18 Granzyme A associated with IL-17 expression was previously described in psoriatic lesions,19 which may indicate, in a psoriatic environment, a predominant role in the maintenance of inflammation, rather than cytotoxicity. The gene discussed is CD4; the disease is discoid lupus erythematosus.