INS and diabetes mellitus: Recent data from the T1D exchange (2016–2018) show that most individuals with T1D in the United States are not meeting glycemic goals.2 At the same time, long-term follow-up data from the Diabetes Control and Complications Trial (DCCT) have shown that one half of the DCCT/Epidemiology of Diabetes Interventions and Complications cohort reported episodes of SH, with SH rates of 35–40 events per 100 patient years,15 further emphasizing the risks of intensive insulin treatment.