Recent data from the T1D exchange (2016–2018) show that most individuals with T1D in the United States are not meeting glycemic goals.2 At the same time, long-term follow-up data from the Diabetes Control and Complications Trial (DCCT) have shown that one half of the DCCT/Epidemiology of Diabetes Interventions and Complications cohort reported episodes of SH, with SH rates of 35–40 events per 100 patient years,15 further emphasizing the risks of intensive insulin treatment. Here, INS is linked to type 1 diabetes mellitus.