Recently, our team identified the upregulationof cyclin M4 (CNNM4),a protein involved in regulating Mg2+ transport,13,14 in the development of nonalcoholic steatohepatitis (NASH)15 and of drug-induced liver disease (DILI) generatedby acetaminophen (paracetamol) overdose.16 Significantly, silencing Cnnm4 restored Mg2+ serum levels and reduced steatosis andother hallmarks of both conditions in animal models. The gene discussed is CNNM4; the disease is steatosis.