Additionally, several motifs were found to be specifically disrupted in certain cancer types (S10 Table), such as M2321_1.02 (TP63) in Bone-Osteosarc, M6446_1.02 (RARG) in Breast-AdenoCA, and M5371_1.02 (EGR4) in Lymph-CLL. The gene discussed is EGR4; the disease is B-cell chronic lymphocytic leukemia.