The most common motifs found across cancer types included one known motif (E2F1, motif ID: M4536_1.02), two unmethylation motifs (UM_235.9_3.32_0.65_1_SGCWCGCGGCGGC and UM_326.6_2.71_0.59_6_CGCGCCCCGY). This evidence concerns the gene E2F1 and cancer.