It is also common for PD to have copathology with other proteinaggregates: cortical Aβ plaques and tau neurofibrillary tanglesalso occur in PD, which may contribute to the rapid cognitive declineand dementia during the disease progression.9 Unlike these insoluble species, smaller soluble aggregates formearlier in the protein aggregation process. The gene discussed is MAPT; the disease is Parkinson disease.