These findings raised the question regarding the actual biological function and the physiological role of MALAT1. Since then, MALAT1 has been shown to be induced upon different types of cellular stress, such as hypoxia in endothelial cells (Michalik et al. 2014), treatment with chemotherapeutic drugs in multiple myeloma (Handa et al. 2017), or lipopolysaccharide treatment in macrophages (Zhao et al. 2016). Here, MALAT1 is linked to AL amyloidosis.