TARDBP and amyotrophic lateral sclerosis: TDP-43 has been associated with the development of amyotrophic lateral sclerosis (ALS) and an ALS-related mutation (D169G) of TDP-43 has been shown to impair NEAT1-mediated LLPS and nuclear body formation, resulting in an accumulation of TDP-43 in stress granules instead (Fig. 4c).