To determine the influence of the level of HLA‐E surface expression on the malignant cells, we inoculated HLA‐Elow (non‐transfected) and HLA‐Ehigh (transfected) Cal‐27 tumor‐cell variants on opposite flanks of Rag2−/‐IL2Rγ−/− mice (Fig 7D). This evidence concerns the gene RAG2 and neoplasm.