To confirm the sequencing findings, we proved that the protein level of TNIP1 was decreased, accompanied by upregulated FTO, in the retinal fibrovascular membranes of the patients with diabetic retinopathy (Figure 4A and Supplemental Figure 5A), diabetic murine retinas (Figure 4B), and HRMECs treated with high glucose (Figure 4C). Here, TNIP1 is linked to diabetic retinopathy.