The results revealed upregulated FTO, accompanied by decreased TNIP1 and elevated NF-κB (p105/p50) levels in EC Ftofl/fl mice with diabetes, whereas in EC FtoΔ/Δ mice, upregulated TNIP1 with suppressed NF-κB was observed (Figure 6A). The gene discussed is NFKB1; the disease is diabetes mellitus.