In addition, Piezo1 monoclonal antibodies that induced Piezo1 internalization in human ESCC tumor cells when administered together with the antineoplastic agent monomethyl auristatin E preferentially killed ESCC tumor cells with high Piezo1 expression and suppressed tumor progression in ESCC xenograft tumor models, suggesting that Piezo1 may provide a novel target for ESCC (140). Here, PIEZO1 is linked to esophageal squamous cell carcinoma.