PIEZO1 and pancreatitis: The Piezo1 agonist Yoda1 increased [Ca2+]i in pancreatic acinar cells and, in high concentrations, caused a sustained [Ca2+]i elevation that led to sustained mitochondrial depolarization, trypsinogen activation, and lactate dehydrogenase (LDH) release, reproducing many features of pancreatitis in vitro (26, 33) (Figure 1A).