Ablating either Trpv1 or Piezo2 in TRPV1-expressing colonic neurons reduced action potential firing by visceral afferents and visceromotor response in mouse models of zymosan-induced IBS and partial colon obstruction, raising the possibility that Piezo2 and TRPV1 could be targets for treating visceral pain caused by mechanical distension or stretch and may be relevant to visceral pain conditions such as inflammatory bowel disease, IBS, or intestinal obstruction (114) in which either excessive stretch or hypersensitivity to normal stretch may occur (Figure 2). This evidence concerns the gene PIEZO2 and intestinal obstruction.