ESR1 and allergic rhinitis: Key targets for allergic rhinitis and asthma were EGFR, SRC, ESR1, ALB, and MAPK8, and allergic rhinitis and asthma syndrome were the “same airway disease.” In conclusion, EGFR, SRC, ESR1, ALB, and MAPK8 are most likely the primary targets of aloin in inhibiting CARAS and play a crucial role in reducing CARAS inflammation.