In some studies, there were changes in the production of proinflammatory cytokines and reactive oxygen species, the expression of endothelial nitric oxide synthase, the development of cardiac hypertrophy and fibrosis, the stability of atherosclerotic plaques and the reactivity of platelets (Oesterle et al., 2017; Tian et al., 2017). Here, NOS3 is linked to cardiac hypertrophy.