Some studies have shown that statins can regulate signal transducer and activator of transcription 6 (STAT6), phosphatase and tensin homolog (PTEN), jumonji domain-containing protein-3 (JMJD3), etc., which are essential in the progression of CKD (An et al., 2022; An et al., 2023). The gene discussed is PTEN; the disease is chronic kidney disease.