Activation of Akt can induce the expression of EMT-inducible transcription factors and phosphorylate Snail1 by inhibiting GSK-3β or activating NF-κB to promote EMT in squamous cell carcinoma cells (L. Zhang et al., 2013; Kaufhold and Bonavida, 2014). This evidence concerns the gene NFKB1 and squamous cell carcinoma.