HELT and Myocardial fibrosis: Liu et al. (2019) investigated the role of miR-29b and its effect on myocardial infarction (MI) in rats through the Notch signaling pathway. The study demonstrated that downregulation of miR-29b in the MI group was associated with increased expression of Notch1, DII4, Hesl, and NICD1, suggesting that miR-29b inhibits myocardial fibrosis and cardiac hypertrophy by activating the Notch signaling pathway, providing protection against MI. Matsuda et al. (2014) investigated the impact of Notch signaling on human cardiac stem cells (CSCs) and their therapeutic potential in an AMI rat model.