The JNK signaling pathway is an evolutionarily conserved kinase cascade composed of distinct mitogen-activated protein kinases (MAPKs) (Zeke et al., 2016), which is activated in response to a variety of stimuli, including DNA damage, oxidative stress, infection, and inflammatory cytokines (Tournier et al., 2001; Yoshida et al., 2005; Tafesh-Edwards and Eleftherianos, 2020). The gene discussed is MAPK8; the disease is infection.