NFKB1 and breast cancer: Furthermore, a large amount of evidence indicates that COX-2 is overexpressed in human BC and BC animal models, and it is closely related to the progression, prognosis, and recurrence of BC (Shirahama et al., 2001; Klein et al., 2005), and NF-κB is closely related to the expression of COX-2 mRNA (Garg and Aggarwal, 2002).