AKT1 and breast cancer: Previous studies have shown that the occurrence of BC is not only the result of the involvement of multiple oncogenes (ras, p53, RB1, FGFR3, EGFR), but is also related to the abnormal activation of multiple signaling pathways (PI3K/Akt, Wnt/β-catenin, JAK/STAT, Notch, NF-κB, MAPK, Hedgehog) (Zhang et al., 2015; Chestnut et al., 2021).