Other lncRNAs implicated in PI3K signaling pathway and DOX resistance included FOXD2-AS1 in BC and DUXAP8 in B-cell acute lymphoblastic leukemia (B-ALL), further uncovering the central role of PI3K pathway in cancer DOX resistance (Nong et al., 2021; Zhang et al., 2022). Here, PIK3CA is linked to cancer.