In our study, we observed that CRSwNP occurs with similar frequency in patients with atopic asthma and patients with nonatopic asthma and that total IgE, which is correlated with eosinophil and type 2 biomarkers,23 is significantly higher in patients with severe asthma with CRSwNP independently of their allergic status. This evidence concerns the gene IGHE and atopic asthma.