This finding agrees with previous findings regarding the role of IgE in patients with intrinsic asthma and patients with CRSwNP and the possible role of bacterial superantigens in the pathophysiology of patients with severe asthma and high IgE levels47,48 differing from that of patients with AR in terms of polyclonal IgE while indicating the importance of assessing upper airway disease when phenotyping asthma. The gene discussed is IGHE; the disease is asthma.