Of note, the WDR5 or G9a dependency was not dependent on MYCN amplification status (Fig. S7E), which is possible due to the high expression of c-Myc in MYCN non-amplified NB cell lines (47), while WDR5 and G9a have been shown to mediate c-MYC function in the other types of cancers (39,41). Here, EHMT2 is linked to neuroblastoma.