In cancer cells, it has been shown that activation of ARF6 (ADP-Ribosylation Factor 6), ADP Ribosylation Factor 1 (ARF1), and small GTP-binding proteins lead to phosphorylation of the myosin side chain of myosin and contraction of actomyosin, permitting MV to detach from the membrane (Nabhan et al., 2012). Here, ARF1 is linked to cancer.