Previous studies have established this by demonstrating that JAG1 is highly expressed in metastatic prostate cancer (Santagata et al., 2004; Pedrosa et al., 2016) and that high-level JAG1-NOTCH expression is observed in the angiogenesis of breast cancer (Reedijk et al., 2005). This evidence concerns the gene JAG1 and metastatic prostate carcinoma.