MKI67 and neoplasm: HE staining of lung tissue harvested three weeks after tumor cell injection revealed more metastatic tumors in H-TDE-pretreated mice than in N-TDE-pretreated mice (Fig. 2I); Number of metastasis was measured by analyzing tumor niche > 0.5 mm from H&E-stained slides with maximum cross-section of paraffin-embedded lungs and representative panoramic pictures were present in Fig. S3D. IHC staining (Fig. 2J) showed that Ki67-positive staining was also significantly increased in H-TDE-pretreated mice.