Furthermore, GSDMBiso3 and GSDMBiso4 account for 75% of total GSDMB transcripts in small intestinal mucosal and rectal epithelial cells, as well as over 38% of total GSDMB transcripts in colonic epithelial cells, indicating that GSDMB-mediated pyroptosis may play a pivotal role in gastrointestinal diseases such as IBD 65. Here, GSDMB is linked to gastrointestinal disease.