GZMA and cancer: In 2020, Zhou and colleagues reported that granzyme A (GzmA) derived from natural killer (NK) and/or CD8+ T cells cleaved GSDMB at K244 (major cleavage site) and K229 (minor cleavage site), which was conserved in GSDMBiso1-4 in a colon cancer cell line, resulting in pyroptosis in cancer cells 20.