Regarding the mechanism of autophagy inhibition in KCs, Liang et al. deciphered that the m6A reader protein YTH Domain Containing 1 (YTHDC1) was inhibited in KCs in a high glucose environment, and YTHDC1 interacted with ELAVL1/HuR to regulate the expression of autophagy receptor SQSTM1. The gene discussed is YTHDC1; the disease is dry eye syndrome.