Recent studies have also suggested that the MAT1A:MAT2A expression ratio could be a potential biomarker for predicting the progression and prognosis of human HCC: a higher MAT1A:MAT2A ratio has been shown to be negatively correlated with cell proliferation and genomic instability and positively correlated with apoptosis and global DNA methylation 110. The gene discussed is MAT1A; the disease is hepatocellular carcinoma.