Adipocyte-specific ablation of IL-27R using Il27rafl/fl AdipoqCre or Il27rafl/flUCP1-Cre-ERT mice resulted in increased HFD-induced obesity and metabolic syndrome (129), although IL-27R ablation in brown adipocytes showed milder effect. The gene discussed is IL27RA; the disease is obesity due to melanocortin 4 receptor deficiency.