APOE and atherosclerosis: Hypertrophy of thoracic PVAT adipocytes was detected in Apoe-/- mice fed with western diet (WD) as compared to C57BL/6 wild type controls; however similar lipid droplet number and size in PVAT adipocytes was observed when mice were fed with chow diet, indicating that increase in adipocyte size and droplet accumulation is happening during progression of atherosclerosis (45).