Figure 6E also showed that the number of CD8+ T cells in the tumor tissue of the MLN8237 group decreased, and the number of CD8+ T cells in the anti-PD-L1 antibody group increased significantly. The number of CD8+ T cells in tumor tissues in the combination group (MLN8237 and anti-PD-L1 antibody) was more than that in the MLN8237 group and less than that in the anti-PD-L1 antibody group. Here, CD274 is linked to neoplasm.