EVs containing IFITM3 were able to be delivered from pregnant mice to the fetuses and suppress ZIKV infection in both mothers and fetuses, while sEVs that overexpress rabies virus glycoprotein were capable of transplacental delivery of anti-ZIKV siRNA to the fetus brain in mice (58, 59). This evidence concerns the gene IFITM3 and Zika virus infectious disease.