The other significant difference between both stimuli was the MDM downregulation of lysosomal acid hydrolases and genes encoding some subunits of the NADPH oxidase complex, exclusively after infection of MDMs with Mtb. Additionally, except for p47phox and p67phox, treatment with hSAA-1 also induced the expression of gp91, the other component of NADPH oxidase. The gene discussed is NCF1; the disease is infection.