As mentioned above, infection with Mtb also induced a large number of genes encoding chemokines of the CC and CXC subfamilies, especially chemokines interacting with the receptors CCR5 (CCL3, CCL4, CCL5, CCL8), CXCR1 (CXCL1, CXCL5, CXCL6, CXCL8), CXCR2 (CXCL2, CXCL3, CXCL7), and CXCR3 (CXCL9, CXCL10, CXCL11); however, the receptors CXCR1 and CXCR2 per se were downregulated. This evidence concerns the gene CCL4 and infection.