After IL-17A blockade, KC expression of IL36G, S100A8, DEFB4A, and DEFB4B in S. corneum and S. granulosum decreased in posttreatment psoriasis lesional skin compared to pretreatment psoriasis lesional skin (Figure 6B and Supplementary Table 4, p < 0.05). This evidence concerns the gene IL36G and psoriasis.