When we segregated DC subset (mature DC and semimature DC) clusters in the scRNA-seq data and compared their transcriptome, mature DCs in psoriasis skin were characterized by relatively high expression of MHC class II molecules (HLA-DRA and HLA-DPB1) and upregulated maturation markers [CD86 (48) and DC-LAMP (LAMP3) (49)] (16) (Figure 5A). The gene discussed is CD86; the disease is psoriasis.