When we compared KC transcriptome in different epidermal layers, the expression of IL-17-driven inflammatory mediators (IL36G, S100A8, DEFB4A, and DEFB4B) was localized to suprabasal layers (S. corneum, S. granulosum, and S. spinosum) in pretreatment psoriasis lesional skin (Figure 6B). The gene discussed is CALCA; the disease is psoriasis.