Reflecting the decreased T-cell numbers by systemic IL-17A blockade, total skin transcriptome of T17 responses (IL17A, IL26, IL12B, and IL20) (3, 28), T-cell regulation (IL24 and CTLA4) (29, 30), resident memory T-cells (Trms) [ITGAE (CD103)] (31) and regulatory T-cells (Tregs) (FOXP3) (32) was decreased in posttreatment psoriasis lesional skin compared to pretreatment psoriasis lesional skin in both microarray and RT-PCR experiments (Figures 2B, C, p < 0.05). Here, CTLA4 is linked to psoriasis.