Instead, skin immune cell subset transcriptome analyses of the semimature DC cluster, which we previously reported as regulatory DCs in psoriasis skin (16), showed regulatory transcriptome promotion by systemic IL-17A blockade in regulatory DCs – 1) The proportion of semimature DCs expressing regulatory DC markers of BDCA-3 (THBD) (51) and DCIR (CLEC4A) (52) was increased in posttreatment psoriasis lesional skin compared to pretreatment psoriasis lesional skin (Figure 5C). Here, IL17A is linked to psoriasis.