IL12B and psoriasis: Since the IL-23/T17 axis cytokine sources (T-cells, DCs, and KCs) were decreased in the predetermined volume of skin biopsy tissue (6 mm punch), total skin transcriptome of IL-23/T17 axis cytokines (IL17A and IL26 from T-cells, IL23A, IL12B, and IL20 from DCs, and S100A8 and IL36 from KCs) was decreased in posttreatment psoriasis lesional skin compared to pretreatment psoriasis lesional skin (Figure 2B).