Reflecting the decreased KC hyperproliferation by systemic IL-17A blockade, total skin transcriptome of KC cytokines that stimulate DCs and T-cells in feed-forward mechanisms (S100A8 and IL36G) (3) was decreased in posttreatment psoriasis lesional skin compared to pretreatment psoriasis lesional skin in both microarray and RT-PCR experiments (Figures 2B, C, p < 0.05). The gene discussed is CALCA; the disease is psoriasis.