Reflecting that inflammation in the upper layers of the epidermis determines psoriasis disease severity (erythema, thickness, and scaling components of Psoriasis Area-and-Severity Index (PASI)), KC expression of IL36G, DEFB4A, and DEFB4B in S. corneum and S. granulosum was correlated with PASI (Figure 6C, p < 0.05). This evidence concerns the gene CALCA and Erythema.