TBCE and psoriasis: For single-cell transcriptome modification of the IL-23/T17 cell axis induced by systemic IL-17A blockade, our study showed that 1) The expression of IL23A in dendritic cell subsets in psoriasis skin lesions was downregulated by systemic IL-17A blockade, potentially by blocking the entire feed-forward inflammatory amplification loop between T-cells, DCs, and KCs (Figure 5A), 2) Systemic IL-17A blockade removed 100% of IL17A-expressing T-cells.