DEFB4B and psoriasis: When we compared KC transcriptome in different epidermal layers, the expression of IL-17-driven inflammatory mediators (IL36G, S100A8, DEFB4A, and DEFB4B) was localized to suprabasal layers (S. corneum, S. granulosum, and S. spinosum) in pretreatment psoriasis lesional skin (Figure 6B).