When we compared KC transcriptome in different epidermal layers, the expression of IL-17-driven inflammatory mediators (IL36G, S100A8, DEFB4A, and DEFB4B) was localized to suprabasal layers (S. corneum, S. granulosum, and S. spinosum) in pretreatment psoriasis lesional skin (Figure 6B). This evidence concerns the gene S100A8 and psoriasis.