IL17A and psoriasis: Although semimature DC cell numbers were decreased after systemic IL-17A blockade, regulatory transcriptome expression of the semimature DCs was increased after systemic IL-17A blockade – 1) The proportion of semimature DCs expressing regulatory DC markers of BDCA-3 (THBD) (51) and DCIR (CLEC4A) (52) was increased in posttreatment psoriasis lesional skin compared to pretreatment psoriasis lesional skin (Figure 5C).