After IL-17A blockade, KC expression of IL36G, S100A8, DEFB4A, and DEFB4B in S. corneum and S. granulosum decreased in posttreatment psoriasis lesional skin compared to pretreatment psoriasis lesional skin (Figure 6B and Supplementary Table 4, p < 0.05). The gene discussed is DEFB4B; the disease is psoriasis.