In vivo, the immunization of naïve mice with myeloid dendritic cells co-cultured with NETs induces ANCA production and autoimmune vasculitis, whereas the immunization with pretreatment of DNase I reduced ANCA production and subsequent vasculitis (2), indicating that DNA released from NET-forming neutrophils is needed to maintain the antigenicity for ANCA production. This evidence concerns the gene DNASE1 and vasculitis.