Moreover, they suggest that the suppression of R5-tropic HIV-1 infection of iDCs observed in the co-cultures of iDCs-R5-tropic HIV-1 and GPI-scFv X5-expressing CEMss-CCR5 cells is not due to inhibition of trans-infection of the T cells by GPI-scFv X5. Here, CCR5 is linked to HIV-1 infection.