(GSE19069 and GSE58445), the largest sample size of RNA sequencing for AITL to date, revealed that CD8+TILs in the high CTL group were more prone to exhaustion-related biological changes and were involved in regulating exhaustion, the obvious deficiency in biological function, and immune suppression of the TME. The gene discussed is CD8A; the disease is angioimmunoblastic T-cell lymphoma.