Further analysis demonstrated that the proportion of CD8+TILs positively correlated with the expression as well as types of IC at the protein and transcription levels, indicating that the more CD8+TILs, the more exhausted CD8+TILs were induced by the overexpression of IC (21) in AITL. The gene discussed is CD8A; the disease is angioimmunoblastic T-cell lymphoma.