To further explore the relationship between the exhaustion status of CD8+TILs and their possible negative impact on prognosis in AITL, we evaluated the functional status associated with CD8+TILs exhaustion from multiple biological aspects (9, 10) at the gene transcription level to reveal the anti-tumor function of CD8+TILs within the high- and low-CTL groups. Here, CD8A is linked to neoplasm.