It has been reported that elevated MDSCs could contribute to tumor progression by remodeling TME through autocrine and paracrine (35–37), and a number of soluble factors secreted by MDSCs, such as IL-6, IL-23, HGF, and VEGF, in various tumors including CRC were associated with poor chemotherapeutic effect (31). This evidence concerns the gene HGF and colorectal carcinoma.